Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P59941 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Mus musculus |
sirtuin 6 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | sirtuin 6 protects the heart from hypoxic damage. The protective mechanism of sirtuin 6 overexpression includes the activation of pAMPKalpha pathway, the increased proteinlevel of B-cell lymphoma 2, the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells, the decrease of reactive oxygen species, and the reduction in the protein level of phosphor-protein kinase B during hypoxia | Mus musculus |